医薬品リファレンス
Lesinurad
Lesinurad is a medicine in the class genitourinary.
- 薬効分類: Genitourinary
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Genitourinary
- 既知の相互作用
- 58 (重大: 1 · 中等度: 23 · 軽度: 34)
- 商品名
- 1
作用のしくみ
Selective uric acid reabsorption inhibitor (SURI); it acts by inhibiting the urate transporter, URAT1, which is responsible for the majority of the renal reabsorption of uric acid. It also inhibits organic anion transporter 4 (OAT4), a uric acid transporter associated with diuretic-induced hyperuricemia
成人の通常用量（添付文書の要約）
Hyperuricemia: 200 mg PO qDay in combination with a xanthine oxidase inhibitor (ie, allopurinol or febuxostat)
妊娠と授乳
- 妊娠
- Unknown Withdrawn product (Zurampic, discontinued from 2019). No human pregnancy data; animal studies showed no harm. EU label: as a precaution, preferably avoid in pregnancy; hormonal contraception alone may not be reliable during use. Gout treatment can usually wait.
- 授乳
- Unknown Withdrawn product. Not known if it passes into human milk; it was found in rat milk. EU label: should not be used while breastfeeding, as a risk to the infant cannot be excluded. No LactMed record; choose another treatment.
報告されている副作用
- Headache
- Influenza
- Renal failure
- GERD
- Increased creatinine
禁忌
- Severe renal impairment (estimated CrCl <30 mL/min), end-stage renal disease, kidney transplant recipients, or patients on dialysis
- Tumor lysis syndrome or Lesch-Nyhan syndrome
注意が必要な方
- Contraindicated in Tumor lysis syndrome or Lesch-Nyhan syndrome.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (58)
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
- Ethinyl estradiol-drospirenone + Lesinurad Moderate
- Ethinyl estradiol-levonorgestrel + Lesinurad Moderate
- Ethinylestradiol + Lesinurad Moderate
- Etonogestrel + Lesinurad Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Lesinuradの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Lesinurad used for?
Lesinurad is a medicine in the class genitourinary.
What side effects have been reported with Lesinurad?
Headache, Influenza, Renal failure, GERD, Increased creatinine.
Can Lesinurad be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Withdrawn product (Zurampic, discontinued from 2019). No human pregnancy data; animal studies showed no harm. EU label: as a precaution, preferably avoid in pregnancy; hormonal contraception alone may not be reliable during use. Gout treatment can usually wait. Breastfeeding: Unknown. Withdrawn product. Not known if it passes into human milk; it was found in rat milk. EU label: should not be used while breastfeeding, as a risk to the infant cannot be excluded. No LactMed record; choose another treatment.
What does Lesinurad interact with?
MediHelp lists 58 known interactions for Lesinurad. Major: 1 · Moderate: 23 · Minor: 34. The most serious include Norethisterone, Acetylsalicylic acid, Amiodarone.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
