相互作用
Acetylsalicylic acid + Prasugrel
重症度: 重大
Acetylsalicylic acid and Prasugrel: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Aspirin and prasugrel are combined deliberately in acute coronary syndrome and after stenting, but together they substantially increase the risk of major and fatal bleeding. Risk is higher in elderly patients, those with low body weight, or with prior stroke.
この相互作用をわかりやすく説明すると
Acetylsalicylic acid and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
なぜ起こるのか
Additive platelet inhibition through irreversible COX-1 blockade (aspirin) and irreversible P2Y12 receptor blockade (prasugrel).
対処法
Use only when indicated, keep aspirin at low maintenance dose, and monitor for bleeding and hemoglobin; limit duration according to guidelines and consider alternatives in high-bleeding-risk patients.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Acetylsalicylic acidとPrasugrelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Acetylsalicylic acidのその他の相互作用
Prasugrelのその他の相互作用
よくある質問
Can I take Acetylsalicylic acid with Prasugrel?
MediHelp rates the interaction as major. Acetylsalicylic acid and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aspirin and prasugrel are combined deliberately in acute coronary syndrome and after stenting, but together they substantially increase the risk of major and fatal bleeding. Risk is higher in elderly patients, those with low body weight, or with prior stroke.
How serious is the interaction between Acetylsalicylic acid and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when indicated, keep aspirin at low maintenance dose, and monitor for bleeding and hemoglobin; limit duration according to guidelines and consider alternatives in high-bleeding-risk patients.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
