相互作用
Apixaban + Prasugrel
重症度: 重大
Apixaban and Prasugrel: major interaction.
最終更新日
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概要
Prasugrel is a potent antiplatelet and apixaban is an anticoagulant. Together they substantially increase the risk of major bleeding.
この相互作用をわかりやすく説明すると
Apixaban and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Prasugrel belongs to Cardiovascular.
なぜ起こるのか
Additive hemostatic impairment from irreversible P2Y12 inhibition and factor Xa inhibition.
対処法
Avoid unless clearly indicated. In patients needing both, clopidogrel is generally preferred with an anticoagulant.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApixabanとPrasugrelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Apixabanのその他の相互作用
Prasugrelのその他の相互作用
よくある質問
Can I take Apixaban with Prasugrel?
MediHelp rates the interaction as major. Apixaban and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prasugrel is a potent antiplatelet and apixaban is an anticoagulant. Together they substantially increase the risk of major bleeding.
How serious is the interaction between Apixaban and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless clearly indicated. In patients needing both, clopidogrel is generally preferred with an anticoagulant.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
