相互作用
Adagrasib + Crizotinib
重症度: 重大
Adagrasib and Crizotinib: major interaction.
最終更新日
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概要
Both drugs prolong the QTc interval, and adagrasib also inhibits CYP3A4, which raises crizotinib exposure. Together they increase the risk of torsades de pointes and serious arrhythmias.
この相互作用をわかりやすく説明すると
Adagrasib and Crizotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Adagrasib belongs to Oncology; Crizotinib belongs to Oncology.
なぜ起こるのか
Additive QTc prolongation, with adagrasib CYP3A4 inhibition further raising crizotinib concentrations.
対処法
Avoid the combination if possible. If unavoidable, obtain baseline and serial ECGs, and correct potassium and magnesium.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AdagrasibとCrizotinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Crizotinibのその他の相互作用
Adagrasibのその他の相互作用
よくある質問
Can I take Adagrasib with Crizotinib?
MediHelp rates the interaction as major. Adagrasib and Crizotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QTc interval, and adagrasib also inhibits CYP3A4, which raises crizotinib exposure. Together they increase the risk of torsades de pointes and serious arrhythmias.
How serious is the interaction between Adagrasib and Crizotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If unavoidable, obtain baseline and serial ECGs, and correct potassium and magnesium.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
