相互作用
Crizotinib + Saquinavir
重症度: 併用禁忌
Crizotinib and Saquinavir: contraindicated interaction.
最終更新日
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概要
Both drugs prolong the QT interval and saquinavir is a strong CYP3A4 inhibitor that can raise crizotinib concentrations. Together they increase the risk of serious ventricular arrhythmias including torsades de pointes.
この相互作用をわかりやすく説明すると
Crizotinib and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive QT prolongation with CYP3A4 inhibition by saquinavir increasing crizotinib exposure.
対処法
Avoid the combination and choose an antiretroviral not affecting QT or CYP3A4. If unavoidable, obtain baseline and serial ECGs and correct electrolytes.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CrizotinibとSaquinavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Crizotinibのその他の相互作用
よくある質問
Can I take Crizotinib with Saquinavir?
MediHelp rates the interaction as contraindicated. Crizotinib and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval and saquinavir is a strong CYP3A4 inhibitor that can raise crizotinib concentrations. Together they increase the risk of serious ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Crizotinib and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiretroviral not affecting QT or CYP3A4. If unavoidable, obtain baseline and serial ECGs and correct electrolytes.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
