相互作用
Adenovirus types 4 and 7 live + Irinotecan
重症度: 重大
Adenovirus types 4 and 7 live and Irinotecan: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Irinotecan is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may replicate excessively or fail to provoke adequate immunity. This raises the risk of vaccine-related infection and reduced protection.
この相互作用をわかりやすく説明すると
Adenovirus types 4 and 7 live and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Cytotoxic immunosuppression impairs the immune response to live attenuated virus, allowing uncontrolled replication and reducing vaccine efficacy.
対処法
Avoid live vaccines during irinotecan therapy and for at least 3 months after stopping, unless the immune status is confirmed to have recovered. Give vaccines before starting chemotherapy where possible.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Adenovirus types 4 and 7 liveとIrinotecanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Irinotecanのその他の相互作用
よくある質問
Can I take Adenovirus types 4 and 7 live with Irinotecan?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Irinotecan is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may replicate excessively or fail to provoke adequate immunity. This raises the risk of vaccine-related infection and reduced protection.
How serious is the interaction between Adenovirus types 4 and 7 live and Irinotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during irinotecan therapy and for at least 3 months after stopping, unless the immune status is confirmed to have recovered. Give vaccines before starting chemotherapy where possible.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Apalutamide. The full list is on the Irinotecan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
