相互作用
Carbamazepine + Irinotecan
重症度: 重大
Carbamazepine and Irinotecan: major interaction.
最終更新日
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概要
Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of irinotecan. The result is altered irinotecan and SN-38 disposition, with reduced exposure and possible loss of efficacy.
この相互作用をわかりやすく説明すると
Carbamazepine and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Irinotecan belongs to Oncology.
なぜ起こるのか
Enzyme induction by carbamazepine increases metabolic clearance of irinotecan
対処法
Avoid where possible by choosing a non-inducing alternative; if unavoidable, monitor clinical response (and drug levels where available) and consider a higher irinotecan dose only per specialist advice.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CarbamazepineとIrinotecanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbamazepineのその他の相互作用
Irinotecanのその他の相互作用
よくある質問
Can I take Carbamazepine with Irinotecan?
MediHelp rates the interaction as major. Carbamazepine and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of irinotecan. The result is altered irinotecan and SN-38 disposition, with reduced exposure and possible loss of efficacy.
How serious is the interaction between Carbamazepine and Irinotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible by choosing a non-inducing alternative; if unavoidable, monitor clinical response (and drug levels where available) and consider a higher irinotecan dose only per specialist advice.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
