医薬品リファレンス
Irinotecan
Irinotecan is a medicine in the class oncology. It is used for colorectal cancer.
- 薬効分類: Oncology
- 効能・効果: colorectal cancer
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- ATCコード
- L01CE02
- 一般的な剤形
- 注射剤, 点滴静注剤
- 一般的な規格
- 40 mg/2 ml, 20 mg/ml, 100 mg/5 ml
- 既知の相互作用
- 174 (併用禁忌: 2 · 重大: 49 · 中等度: 93 · 軽度: 30)
- 商品名
- 25
- 国・市場
- 5
何に使われるか
作用のしくみ
Binds to topoisomerase I to produce double-strand breaks in DNA
成人の通常用量（添付文書の要約）
Regimen 1 (Weekly): 125 mg/m² IV infusion over 90 minutes on days 1, 8, 15, 22, then 2 weeks off, then repeat
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm: embryo deaths and birth defects in rats and rabbits below human exposure; human data are limited. Avoid; verify pregnancy status. Contraception after the last dose: women 6 months, men 3 months (liposomal form: 7 and 4 months).
- 授乳
- Unsafe Irinotecan and its active metabolite pass into milk, the metabolite for up to a week after a dose. US labels: do not breastfeed during treatment and for 7 days after the last dose (liposomal form: 1 month). LactMed: higher doses may need a longer break.
報告されている副作用
- Diarrhea
- Nausea
- Leukopenia
- Anemia
- Neutropenia
- Thrombocytopenia
注意が必要な方
- Drug is subject to photodegradation, especially in neutral and alkaline solutions
- Avoid pregnancy; can cause fetal harm
- Renal impairment and acute renal failure reported; usually in patients who became volume depleted from severe vomiting and/or diarrhea
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (174)
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
- Clarithromycin + Irinotecan Major
- Cobicistat + Irinotecan Major
- Conivaptan + Irinotecan Major
- Cyclosporin + Irinotecan Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Irinotecanの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Irinotecan used for?
Irinotecan is a medicine in the class oncology. It is used for Colorectal cancer.
What side effects have been reported with Irinotecan?
Diarrhea, Nausea, Leukopenia, Anemia, Neutropenia, Thrombocytopenia.
Can Irinotecan be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: embryo deaths and birth defects in rats and rabbits below human exposure; human data are limited. Avoid; verify pregnancy status. Contraception after the last dose: women 6 months, men 3 months (liposomal form: 7 and 4 months). Breastfeeding: Unsafe. Irinotecan and its active metabolite pass into milk, the metabolite for up to a week after a dose. US labels: do not breastfeed during treatment and for 7 days after the last dose (liposomal form: 1 month). LactMed: higher doses may need a longer break.
What does Irinotecan interact with?
MediHelp lists 174 known interactions for Irinotecan. Contraindicated: 2 · Major: 49 · Moderate: 93 · Minor: 30. The most serious include Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
