相互作用
Alfentanil + Clemastine
重症度: 重大
Alfentanil and Clemastine: major interaction.
最終更新日
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概要
Concurrent use of an opioid with a sedating antihistamine increases sedation and may add to respiratory depression. Impaired alertness and psychomotor performance are expected, and the risk rises in older or frail patients.
この相互作用をわかりやすく説明すると
Alfentanil and Clemastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression through opioid receptor agonism and H1-antihistamine sedation.
対処法
Monitor sedation level and respiratory rate, and use the lowest effective doses. Prefer a non-sedating antihistamine when feasible.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AlfentanilとClemastineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Clemastineのその他の相互作用
よくある質問
Can I take Alfentanil with Clemastine?
MediHelp rates the interaction as major. Alfentanil and Clemastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of an opioid with a sedating antihistamine increases sedation and may add to respiratory depression. Impaired alertness and psychomotor performance are expected, and the risk rises in older or frail patients.
How serious is the interaction between Alfentanil and Clemastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, and use the lowest effective doses. Prefer a non-sedating antihistamine when feasible.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine buccal, Buprenorphine long-acting. The full list is on the Clemastine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
