相互作用
Buprenorphine long-acting + Clemastine
重症度: 重大
Buprenorphine long-acting and Clemastine: major interaction.
最終更新日
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概要
Long-acting injectable buprenorphine gives prolonged opioid exposure, and a sedating antihistamine adds to drowsiness and psychomotor impairment. Respiratory depression is possible and cannot be reversed quickly because of the depot.
この相互作用をわかりやすく説明すると
Buprenorphine long-acting and Clemastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression from the partial opioid agonist and the sedating H1 antihistamine.
対処法
Prefer a non-sedating antihistamine when an antihistamine is needed. If combined, monitor for sedation and respiratory depression and counsel on driving and alcohol.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Buprenorphine long-actingとClemastineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clemastineのその他の相互作用
よくある質問
Can I take Buprenorphine long-acting with Clemastine?
MediHelp rates the interaction as major. Buprenorphine long-acting and Clemastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Long-acting injectable buprenorphine gives prolonged opioid exposure, and a sedating antihistamine adds to drowsiness and psychomotor impairment. Respiratory depression is possible and cannot be reversed quickly because of the depot.
How serious is the interaction between Buprenorphine long-acting and Clemastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine when an antihistamine is needed. If combined, monitor for sedation and respiratory depression and counsel on driving and alcohol.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
