相互作用
Alprazolam + Chlordiazepoxide-clidinium
重症度: 重大
Alprazolam and Chlordiazepoxide-clidinium: major interaction.
最終更新日
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概要
Combining two benzodiazepines duplicates therapy and increases sedation, psychomotor impairment, falls and respiratory depression risk. There is no therapeutic advantage to the combination in most patients.
この相互作用をわかりやすく説明すると
Alprazolam and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive GABA-A receptor mediated CNS and respiratory depression.
対処法
Avoid concurrent use of two benzodiazepines and consolidate to a single agent. If unavoidable, use the lowest doses for the shortest time and monitor sedation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AlprazolamとChlordiazepoxide-clidiniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chlordiazepoxide-clidiniumのその他の相互作用
Alprazolamのその他の相互作用
よくある質問
Can I take Alprazolam with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Alprazolam and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two benzodiazepines duplicates therapy and increases sedation, psychomotor impairment, falls and respiratory depression risk. There is no therapeutic advantage to the combination in most patients.
How serious is the interaction between Alprazolam and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines and consolidate to a single agent. If unavoidable, use the lowest doses for the shortest time and monitor sedation.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Chlordiazepoxide-clidinium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
