相互作用
Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium
重症度: 重大
Benzhydrocodone / acetaminophen and Chlordiazepoxide-clidinium: major interaction.
最終更新日
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概要
Opioids combined with benzodiazepines such as chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. The risk is dose-related and greatest at the start of combined therapy.
この相互作用をわかりやすく説明すると
Benzhydrocodone / acetaminophen and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression from opioid and GABA-A benzodiazepine effects.
対処法
Reserve the combination for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression and consider naloxone availability.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Benzhydrocodone / acetaminophenとChlordiazepoxide-clidiniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chlordiazepoxide-clidiniumのその他の相互作用
よくある質問
Can I take Benzhydrocodone / acetaminophen with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with benzodiazepines such as chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. The risk is dose-related and greatest at the start of combined therapy.
How serious is the interaction between Benzhydrocodone / acetaminophen and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression and consider naloxone availability.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
