相互作用
Amobarbital + Chlordiazepoxide-clidinium
重症度: 重大
Amobarbital and Chlordiazepoxide-clidinium: major interaction.
最終更新日
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概要
Barbiturates and benzodiazepines together produce additive CNS and respiratory depression. Amobarbital also induces CYP3A4 and may lower chlordiazepoxide levels, making the net effect unpredictable.
この相互作用をわかりやすく説明すると
Amobarbital and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive GABAergic CNS depression, with CYP3A4 induction by amobarbital altering chlordiazepoxide clearance.
対処法
Avoid the combination where possible. If used, give reduced doses and monitor sedation and respiratory status.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとChlordiazepoxide-clidiniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chlordiazepoxide-clidiniumのその他の相互作用
Amobarbitalのその他の相互作用
よくある質問
Can I take Amobarbital with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Amobarbital and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines together produce additive CNS and respiratory depression. Amobarbital also induces CYP3A4 and may lower chlordiazepoxide levels, making the net effect unpredictable.
How serious is the interaction between Amobarbital and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, give reduced doses and monitor sedation and respiratory status.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Belladonna and opium. The full list is on the Chlordiazepoxide-clidinium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
