相互作用
Aluminum hydroxide / magnesium carbonate + Misoprostol
重症度: 中等度
Aluminum hydroxide / magnesium carbonate and Misoprostol: moderate interaction.
最終更新日
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概要
Magnesium-containing antacids can aggravate the diarrhea that is the most common adverse effect of misoprostol. Antacids may also modestly lower systemic exposure to misoprostol acid, though the clinical importance of this is uncertain.
この相互作用をわかりやすく説明すると
Aluminum hydroxide / magnesium carbonate and Misoprostol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Additive osmotic laxative effect of magnesium with misoprostol-induced intestinal secretion and motility, plus possible reduced absorption of the active acid.
対処法
If an antacid is needed, prefer an aluminum- or calcium-based product without magnesium. Monitor for diarrhea and dehydration, especially in elderly patients.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Aluminum hydroxide / magnesium carbonateとMisoprostolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Misoprostolのその他の相互作用
よくある質問
Can I take Aluminum hydroxide / magnesium carbonate with Misoprostol?
MediHelp rates the interaction as moderate. Aluminum hydroxide / magnesium carbonate and Misoprostol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing antacids can aggravate the diarrhea that is the most common adverse effect of misoprostol. Antacids may also modestly lower systemic exposure to misoprostol acid, though the clinical importance of this is uncertain.
How serious is the interaction between Aluminum hydroxide / magnesium carbonate and Misoprostol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, prefer an aluminum- or calcium-based product without magnesium. Monitor for diarrhea and dehydration, especially in elderly patients.
What other medicines interact with Misoprostol?
MediHelp also lists interactions of Misoprostol with, for example, Oxytocin, Aluminum hydroxide / magnesium trisilicate, Citric acid / glucono-delta-lactone / magnesium carbonate. The full list is on the Misoprostol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
