相互作用
Misoprostol + Oxytocin
重症度: 重大
Misoprostol and Oxytocin: major interaction.
最終更新日
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概要
Misoprostol sensitizes the uterus to oxytocin, and giving oxytocin shortly after misoprostol may cause uterine hyperstimulation. This can lead to fetal distress and, rarely, uterine rupture.
この相互作用をわかりやすく説明すると
Misoprostol and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Misoprostol belongs to Gastrointestinal Tract; Oxytocin belongs to Endocrine.
なぜ起こるのか
Additive uterotonic effects through prostaglandin E1 and oxytocin receptor pathways.
対処法
Delay oxytocin start for at least 4 hours after the last misoprostol dose and monitor uterine activity and fetal heart rate continuously.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、MisoprostolとOxytocinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Misoprostolのその他の相互作用
Oxytocinのその他の相互作用
よくある質問
Can I take Misoprostol with Oxytocin?
MediHelp rates the interaction as major. Misoprostol and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Misoprostol sensitizes the uterus to oxytocin, and giving oxytocin shortly after misoprostol may cause uterine hyperstimulation. This can lead to fetal distress and, rarely, uterine rupture.
How serious is the interaction between Misoprostol and Oxytocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay oxytocin start for at least 4 hours after the last misoprostol dose and monitor uterine activity and fetal heart rate continuously.
What other medicines interact with Misoprostol?
MediHelp also lists interactions of Misoprostol with, for example, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate, Citric acid / glucono-delta-lactone / magnesium carbonate. The full list is on the Misoprostol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
