相互作用
Amikacin + Cisplatin
重症度: 重大
Amikacin and Cisplatin: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Both drugs are nephrotoxic and ototoxic, and combined use markedly raises the risk of acute kidney injury and permanent hearing loss.
この相互作用をわかりやすく説明すると
Amikacin and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Cisplatin belongs to Oncology.
なぜ起こるのか
Additive renal tubular and cochlear toxicity.
対処法
Avoid the combination whenever possible. If needed, ensure hydration, monitor creatinine, electrolytes, amikacin levels and hearing.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmikacinとCisplatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amikacinのその他の相互作用
Cisplatinのその他の相互作用
よくある質問
Can I take Amikacin with Cisplatin?
MediHelp rates the interaction as major. Amikacin and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic and ototoxic, and combined use markedly raises the risk of acute kidney injury and permanent hearing loss.
How serious is the interaction between Amikacin and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination whenever possible. If needed, ensure hydration, monitor creatinine, electrolytes, amikacin levels and hearing.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
