相互作用
Amikacin + Piperacillin-tazobactam
重症度: 中等度
Amikacin and Piperacillin-tazobactam: moderate interaction.
最終更新日
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概要
Antipseudomonal penicillins and aminoglycosides are often combined for synergistic bacterial killing. In patients with renal impairment, piperacillin can inactivate aminoglycosides in vitro and in the patient, lowering aminoglycoside levels.
この相互作用をわかりやすく説明すると
Amikacin and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Piperacillin-tazobactam belongs to Anti Bacterial.
なぜ起こるのか
Pharmacodynamic synergy, plus chemical inactivation of the aminoglycoside by the penicillin, particularly when renal clearance is reduced.
対処法
Do not mix in the same infusion line or syringe and give separately. Monitor amikacin concentrations and renal function, especially in renal impairment.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、AmikacinとPiperacillin-tazobactamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Piperacillin-tazobactamのその他の相互作用
Amikacinのその他の相互作用
よくある質問
Can I take Amikacin with Piperacillin-tazobactam?
MediHelp rates the interaction as moderate. Amikacin and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipseudomonal penicillins and aminoglycosides are often combined for synergistic bacterial killing. In patients with renal impairment, piperacillin can inactivate aminoglycosides in vitro and in the patient, lowering aminoglycoside levels.
How serious is the interaction between Amikacin and Piperacillin-tazobactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not mix in the same infusion line or syringe and give separately. Monitor amikacin concentrations and renal function, especially in renal impairment.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Antithrombin alfa, Antithrombin iii. The full list is on the Piperacillin-tazobactam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
