相互作用
Piperacillin-tazobactam + Vancomycin
重症度: 重大
Piperacillin-tazobactam and Vancomycin: major interaction.
最終更新日
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概要
Concurrent use is associated with a higher incidence of acute kidney injury than vancomycin with other beta-lactams. Some of the rise in serum creatinine may reflect reduced tubular secretion, but true kidney injury has been reported. Risk is higher with high vancomycin exposure, critical illness, or other nephrotoxins.
この相互作用をわかりやすく説明すると
Piperacillin-tazobactam and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Piperacillin-tazobactam belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
なぜ起こるのか
Additive or synergistic nephrotoxicity, with possible effects on tubular creatinine secretion; mechanism not fully defined.
対処法
Monitor serum creatinine and urine output frequently and keep vancomycin levels within target. Consider an alternative beta-lactam if renal function declines.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Piperacillin-tazobactamとVancomycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Piperacillin-tazobactamのその他の相互作用
Vancomycinのその他の相互作用
よくある質問
Can I take Piperacillin-tazobactam with Vancomycin?
MediHelp rates the interaction as major. Piperacillin-tazobactam and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use is associated with a higher incidence of acute kidney injury than vancomycin with other beta-lactams. Some of the rise in serum creatinine may reflect reduced tubular secretion, but true kidney injury has been reported. Risk is higher with high vancomycin exposure, critical illness, or other nephrotoxins.
How serious is the interaction between Piperacillin-tazobactam and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output frequently and keep vancomycin levels within target. Consider an alternative beta-lactam if renal function declines.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Amikacin, Antithrombin alfa, Antithrombin iii. The full list is on the Piperacillin-tazobactam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
