相互作用
Amiodarone + Atenolol-chlorthalidone
重症度: 重大
Amiodarone and Atenolol-chlorthalidone: major interaction.
最終更新日
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概要
Amiodarone and atenolol both depress sinus node and AV conduction, so combining them can cause marked bradycardia, AV block or sinus arrest. Risk is greatest in older patients or those with conduction disease, and amiodarone's long half-life prolongs the risk.
この相互作用をわかりやすく説明すると
Amiodarone and Atenolol-chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Atenolol-chlorthalidone belongs to Cardiovascular.
なぜ起こるのか
Additive negative chronotropic and dromotropic effects through beta-blockade and amiodarone's electrophysiologic actions.
対処法
Monitor heart rate and ECG closely when starting or adjusting either drug, and reduce the atenolol dose or stop therapy if symptomatic bradycardia or conduction block occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとAtenolol-chlorthalidoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Atenolol-chlorthalidoneのその他の相互作用
Amiodaroneのその他の相互作用
よくある質問
Can I take Amiodarone with Atenolol-chlorthalidone?
MediHelp rates the interaction as major. Amiodarone and Atenolol-chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone and atenolol both depress sinus node and AV conduction, so combining them can cause marked bradycardia, AV block or sinus arrest. Risk is greatest in older patients or those with conduction disease, and amiodarone's long half-life prolongs the risk.
How serious is the interaction between Amiodarone and Atenolol-chlorthalidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG closely when starting or adjusting either drug, and reduce the atenolol dose or stop therapy if symptomatic bradycardia or conduction block occurs.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Bendroflumethiazide. The full list is on the Atenolol-chlorthalidone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
