相互作用
Amiodarone + Dofetilide
重症度: 併用禁忌
Amiodarone and Dofetilide: contraindicated interaction.
最終更新日
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概要
Both drugs prolong cardiac repolarization. Combined use increases the risk of marked QT prolongation and torsades de pointes.
この相互作用をわかりやすく説明すると
Amiodarone and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.
なぜ起こるのか
Additive QT prolongation through potassium channel blockade.
対処法
Avoid concurrent use. Because of amiodarone's long half-life, seek specialist advice before starting dofetilide in a recently treated patient, with ECG monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとDofetilideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Dofetilideのその他の相互作用
よくある質問
Can I take Amiodarone with Dofetilide?
MediHelp rates the interaction as contraindicated. Amiodarone and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong cardiac repolarization. Combined use increases the risk of marked QT prolongation and torsades de pointes.
How serious is the interaction between Amiodarone and Dofetilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Because of amiodarone's long half-life, seek specialist advice before starting dofetilide in a recently treated patient, with ECG monitoring.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dronedarone. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
