相互作用
Amiodarone + Amisulpride
重症度: 併用禁忌
Amiodarone and Amisulpride: contraindicated interaction.
最終更新日
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概要
Both drugs prolong the QT interval, and their combination substantially increases the risk of torsades de pointes. Amiodarone's long half-life means the risk persists after it is stopped.
この相互作用をわかりやすく説明すると
Amiodarone and Amisulpride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Amisulpride belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation through blockade of cardiac potassium channels (pharmacodynamic).
対処法
Avoid the combination and choose an antipsychotic with lower QT liability. If it cannot be avoided, use continuous ECG monitoring and keep potassium and magnesium normal.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、AmiodaroneとAmisulprideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Amisulprideのその他の相互作用
よくある質問
Can I take Amiodarone with Amisulpride?
MediHelp rates the interaction as contraindicated. Amiodarone and Amisulpride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and their combination substantially increases the risk of torsades de pointes. Amiodarone's long half-life means the risk persists after it is stopped.
How serious is the interaction between Amiodarone and Amisulpride?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic with lower QT liability. If it cannot be avoided, use continuous ECG monitoring and keep potassium and magnesium normal.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
