相互作用
Amiodarone + Primaquine
重症度: 重大
Amiodarone and Primaquine: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Primaquine can prolong the QT interval, and amiodarone strongly prolongs repolarization, so combined use raises the risk of torsades de pointes. Amiodarone's long half-life means the risk persists after it is stopped.
この相互作用をわかりやすく説明すると
Amiodarone and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Primaquine belongs to Anti Parasitic.
なぜ起こるのか
Additive QT prolongation through effects on cardiac repolarization.
対処法
Avoid the combination where possible, using an alternative antimalarial if feasible. If it is unavoidable, monitor ECG and correct potassium and magnesium.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとPrimaquineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Primaquineのその他の相互作用
Amiodaroneのその他の相互作用
よくある質問
Can I take Amiodarone with Primaquine?
MediHelp rates the interaction as major. Amiodarone and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Primaquine can prolong the QT interval, and amiodarone strongly prolongs repolarization, so combined use raises the risk of torsades de pointes. Amiodarone's long half-life means the risk persists after it is stopped.
How serious is the interaction between Amiodarone and Primaquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using an alternative antimalarial if feasible. If it is unavoidable, monitor ECG and correct potassium and magnesium.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amisulpride, Anagrelide. The full list is on the Primaquine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
