相互作用
Amitriptyline + Dexchlorpheniramine
重症度: 中等度
Amitriptyline and Dexchlorpheniramine: moderate interaction.
最終更新日
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概要
Dexchlorpheniramine is a first-generation antihistamine with sedative and anticholinergic properties like amitriptyline. Together they can increase drowsiness, dry mouth, urinary retention, and confusion.
この相互作用をわかりやすく説明すると
Amitriptyline and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
なぜ起こるのか
Additive CNS depression and antimuscarinic effects.
対処法
Monitor for sedation and anticholinergic effects, especially in older patients. Switch to a non-sedating antihistamine if appropriate.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、AmitriptylineとDexchlorpheniramineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amitriptylineのその他の相互作用
Dexchlorpheniramineのその他の相互作用
よくある質問
Can I take Amitriptyline with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Amitriptyline and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a first-generation antihistamine with sedative and anticholinergic properties like amitriptyline. Together they can increase drowsiness, dry mouth, urinary retention, and confusion.
How serious is the interaction between Amitriptyline and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, especially in older patients. Switch to a non-sedating antihistamine if appropriate.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
