相互作用
Amitriptyline + Diphenoxylate-atropine
重症度: 重大
Amitriptyline and Diphenoxylate-atropine: major interaction.
最終更新日
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概要
Amitriptyline is strongly anticholinergic and sedating, and the atropine and diphenoxylate components add to this. The combination can cause constipation progressing to ileus, urinary retention, tachycardia, confusion and excess sedation.
この相互作用をわかりやすく説明すると
Amitriptyline and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive muscarinic blockade and additive CNS depression.
対処法
Avoid combining where possible, especially in older patients or those with ileus or urinary retention; if used, monitor bowel and bladder function and mental status.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmitriptylineとDiphenoxylate-atropineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Diphenoxylate-atropineのその他の相互作用
Amitriptylineのその他の相互作用
よくある質問
Can I take Amitriptyline with Diphenoxylate-atropine?
MediHelp rates the interaction as major. Amitriptyline and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amitriptyline is strongly anticholinergic and sedating, and the atropine and diphenoxylate components add to this. The combination can cause constipation progressing to ileus, urinary retention, tachycardia, confusion and excess sedation.
How serious is the interaction between Amitriptyline and Diphenoxylate-atropine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in older patients or those with ileus or urinary retention; if used, monitor bowel and bladder function and mental status.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
