相互作用
Amobarbital + Diphenoxylate-atropine
重症度: 重大
Amobarbital and Diphenoxylate-atropine: major interaction.
最終更新日
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概要
Barbiturates and the opioid diphenoxylate cause additive CNS and respiratory depression. Profound sedation is possible, especially with higher doses.
この相互作用をわかりやすく説明すると
Amobarbital and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive CNS depression through GABA-A potentiation and opioid receptor agonism.
対処法
Avoid if possible; otherwise use the lowest doses and monitor sedation and respiratory rate.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとDiphenoxylate-atropineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Diphenoxylate-atropineのその他の相互作用
Amobarbitalのその他の相互作用
よくある質問
Can I take Amobarbital with Diphenoxylate-atropine?
MediHelp rates the interaction as major. Amobarbital and Diphenoxylate-atropine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and the opioid diphenoxylate cause additive CNS and respiratory depression. Profound sedation is possible, especially with higher doses.
How serious is the interaction between Amobarbital and Diphenoxylate-atropine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use the lowest doses and monitor sedation and respiratory rate.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
