相互作用
Amitriptyline + Galantamine
重症度: 中等度
Amitriptyline and Galantamine: moderate interaction.
最終更新日
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概要
Amitriptyline has strong anticholinergic activity that opposes the cholinergic action of galantamine, potentially reducing its benefit in dementia. Anticholinergic burden may also worsen cognition and confusion.
この相互作用をわかりやすく説明すると
Amitriptyline and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Galantamine belongs to Central Nervous System.
なぜ起こるのか
Pharmacodynamic antagonism between muscarinic blockade by amitriptyline and cholinesterase inhibition by galantamine.
対処法
Avoid amitriptyline in patients with dementia where possible and choose a less anticholinergic antidepressant. If combined, monitor cognitive response.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmitriptylineとGalantamineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amitriptylineのその他の相互作用
Galantamineのその他の相互作用
よくある質問
Can I take Amitriptyline with Galantamine?
MediHelp rates the interaction as moderate. Amitriptyline and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline has strong anticholinergic activity that opposes the cholinergic action of galantamine, potentially reducing its benefit in dementia. Anticholinergic burden may also worsen cognition and confusion.
How serious is the interaction between Amitriptyline and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid amitriptyline in patients with dementia where possible and choose a less anticholinergic antidepressant. If combined, monitor cognitive response.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
