相互作用
Galantamine + Memantine-donepezil
重症度: 重大
Galantamine and Memantine-donepezil: major interaction.
最終更新日
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概要
Donepezil and galantamine are both cholinesterase inhibitors, so using them together duplicates therapy and increases cholinergic adverse effects such as nausea, vomiting, bradycardia and syncope. There is no established added cognitive benefit.
この相互作用をわかりやすく説明すると
Galantamine and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Galantamine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
なぜ起こるのか
Duplicate acetylcholinesterase inhibition produces additive cholinergic effects.
対処法
Avoid combining two cholinesterase inhibitors and use only one. If switching, stop one agent before starting the other and monitor tolerability.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、GalantamineとMemantine-donepezilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Memantine-donepezilのその他の相互作用
Galantamineのその他の相互作用
よくある質問
Can I take Galantamine with Memantine-donepezil?
MediHelp rates the interaction as major. Galantamine and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Donepezil and galantamine are both cholinesterase inhibitors, so using them together duplicates therapy and increases cholinergic adverse effects such as nausea, vomiting, bradycardia and syncope. There is no established added cognitive benefit.
How serious is the interaction between Galantamine and Memantine-donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two cholinesterase inhibitors and use only one. If switching, stop one agent before starting the other and monitor tolerability.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
