相互作用
Amoxapine + Isocarboxazid
重症度: 併用禁忌
Amoxapine and Isocarboxazid: contraindicated interaction.
最終更新日
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概要
Combining an MAOI with amoxapine can produce serotonin syndrome and hypertensive reactions. Labeling prohibits concurrent use of MAOIs and tricyclic-type antidepressants.
この相互作用をわかりやすく説明すると
Amoxapine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
MAO inhibition combined with amoxapine's reuptake inhibition of norepinephrine and serotonin leads to excess monoamine activity.
対処法
Do not coadminister. Allow a washout of at least 14 days after stopping isocarboxazid before starting amoxapine, and an adequate washout in the other direction.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmoxapineとIsocarboxazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isocarboxazidのその他の相互作用
よくある質問
Can I take Amoxapine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Amoxapine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAOI with amoxapine can produce serotonin syndrome and hypertensive reactions. Labeling prohibits concurrent use of MAOIs and tricyclic-type antidepressants.
How serious is the interaction between Amoxapine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow a washout of at least 14 days after stopping isocarboxazid before starting amoxapine, and an adequate washout in the other direction.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
