相互作用
Amlodipine-benazepril + Lithium
重症度: 重大
Amlodipine-benazepril and Lithium: major interaction.
最終更新日
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概要
ACE inhibitors can reduce renal lithium clearance and raise serum lithium, leading to toxicity such as tremor, confusion, ataxia and gastrointestinal upset. Cases have occurred days to weeks after starting the ACE inhibitor.
この相互作用をわかりやすく説明すると
Amlodipine-benazepril and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-benazepril belongs to Cardiovascular; Lithium belongs to Central Nervous System.
なぜ起こるのか
ACE inhibitors reduce sodium and glomerular filtration, increasing proximal tubular reabsorption of lithium.
対処法
Avoid if possible; otherwise check serum lithium before and within the first week or so after starting benazepril and after dose changes. Reduce the lithium dose as needed and counsel patients on toxicity symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amlodipine-benazeprilとLithiumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-benazeprilのその他の相互作用
Lithiumのその他の相互作用
よくある質問
Can I take Amlodipine-benazepril with Lithium?
MediHelp rates the interaction as major. Amlodipine-benazepril and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors can reduce renal lithium clearance and raise serum lithium, leading to toxicity such as tremor, confusion, ataxia and gastrointestinal upset. Cases have occurred days to weeks after starting the ACE inhibitor.
How serious is the interaction between Amlodipine-benazepril and Lithium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise check serum lithium before and within the first week or so after starting benazepril and after dose changes. Reduce the lithium dose as needed and counsel patients on toxicity symptoms.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
