相互作用
Lithium + Vandetanib
重症度: 併用禁忌
Lithium and Vandetanib: contraindicated interaction.
最終更新日
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概要
Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death, and lithium may add to this risk. Concurrent QT-prolonging drugs are to be avoided.
この相互作用をわかりやすく説明すると
Lithium and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lithium belongs to Central Nervous System; Vandetanib belongs to Oncology.
なぜ起こるのか
Additive QTc prolongation; vandetanib is a potent QT-prolonging agent with a long half-life.
対処法
Avoid the combination and use an alternative to lithium. If both are unavoidable, monitor ECG and electrolytes frequently.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LithiumとVandetanibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lithiumのその他の相互作用
Vandetanibのその他の相互作用
よくある質問
Can I take Lithium with Vandetanib?
MediHelp rates the interaction as contraindicated. Lithium and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death, and lithium may add to this risk. Concurrent QT-prolonging drugs are to be avoided.
How serious is the interaction between Lithium and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative to lithium. If both are unavoidable, monitor ECG and electrolytes frequently.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Aceclofenac, Acemetacin. The full list is on the Lithium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
