相互作用
Lithium + Thioridazine
重症度: 併用禁忌
Lithium and Thioridazine: contraindicated interaction.
最終更新日
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概要
Thioridazine strongly prolongs the QTc interval and can cause torsades de pointes, and lithium can add to QT effects and electrolyte disturbance. Combined use may also raise the risk of neurotoxicity. Thioridazine labeling carries a boxed warning on QT risk and the pair is generally avoided.
この相互作用をわかりやすく説明すると
Lithium and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lithium belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation, with possible pharmacodynamic neurotoxic synergy.
対処法
Avoid the combination and use a lower-QT-risk antipsychotic. If lithium must be continued, obtain an ECG, check potassium and magnesium, and monitor for neurotoxicity.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LithiumとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lithiumのその他の相互作用
Thioridazineのその他の相互作用
よくある質問
Can I take Lithium with Thioridazine?
MediHelp rates the interaction as contraindicated. Lithium and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine strongly prolongs the QTc interval and can cause torsades de pointes, and lithium can add to QT effects and electrolyte disturbance. Combined use may also raise the risk of neurotoxicity. Thioridazine labeling carries a boxed warning on QT risk and the pair is generally avoided.
How serious is the interaction between Lithium and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a lower-QT-risk antipsychotic. If lithium must be continued, obtain an ECG, check potassium and magnesium, and monitor for neurotoxicity.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Vandetanib, Aceclofenac, Acemetacin. The full list is on the Lithium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
