Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Gentamicin
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Gentamicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin can cause renal tubular damage with magnesium and potassium wasting, and hydrochlorothiazide adds to potassium and magnesium loss. Diuretic-induced volume depletion also raises the risk of aminoglycoside nephrotoxicity and ototoxicity, while valsartan can worsen renal function in volume depletion.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive renal electrolyte wasting, with diuretic volume depletion and angiotensin blockade increasing susceptibility to aminoglycoside nephrotoxicity.
What to do
Monitor serum creatinine, potassium and magnesium, and gentamicin levels during treatment. Consider holding the diuretic and valsartan during acute illness or volume depletion.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
- Atracurium + Gentamicin Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Gentamicin?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gentamicin can cause renal tubular damage with magnesium and potassium wasting, and hydrochlorothiazide adds to potassium and magnesium loss. Diuretic-induced volume depletion also raises the risk of aminoglycoside nephrotoxicity and ototoxicity, while valsartan can worsen renal function in volume depletion.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium, and gentamicin levels during treatment. Consider holding the diuretic and valsartan during acute illness or volume depletion.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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