相互作用
Azilsartan-chlorthalidone + Sparsentan
重症度: 併用禁忌
Azilsartan-chlorthalidone and Sparsentan: contraindicated interaction.
最終更新日
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概要
Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin receptor blockade. This increases the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
この相互作用をわかりやすく説明すると
Azilsartan-chlorthalidone and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azilsartan-chlorthalidone belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
なぜ起こるのか
Additive angiotensin II type 1 receptor blockade with duplicated pharmacodynamic effects.
対処法
Do not coadminister; discontinue the ARB before starting sparsentan and monitor blood pressure, potassium and renal function.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Azilsartan-chlorthalidoneとSparsentanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Azilsartan-chlorthalidoneのその他の相互作用
Sparsentanのその他の相互作用
よくある質問
Can I take Azilsartan-chlorthalidone with Sparsentan?
MediHelp rates the interaction as contraindicated. Azilsartan-chlorthalidone and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin receptor blockade. This increases the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
How serious is the interaction between Azilsartan-chlorthalidone and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; discontinue the ARB before starting sparsentan and monitor blood pressure, potassium and renal function.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Aceclofenac, Aldesleukin. The full list is on the Azilsartan-chlorthalidone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
