相互作用
Amlodipine-valsartan + Sparsentan
重症度: 併用禁忌
Amlodipine-valsartan and Sparsentan: contraindicated interaction.
最終更新日
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概要
Sparsentan itself blocks the angiotensin II receptor, so combining it with valsartan duplicates this effect. This increases the likelihood of hypotension, syncope, hyperkalemia and acute kidney injury.
この相互作用をわかりやすく説明すると
Amlodipine-valsartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amlodipine-valsartan belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
なぜ起こるのか
Additive pharmacodynamic angiotensin II type 1 receptor blockade.
対処法
Do not use together; sparsentan labeling contraindicates concomitant ARBs. Stop the ARB before starting sparsentan.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amlodipine-valsartanとSparsentanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-valsartanのその他の相互作用
Sparsentanのその他の相互作用
よくある質問
Can I take Amlodipine-valsartan with Sparsentan?
MediHelp rates the interaction as contraindicated. Amlodipine-valsartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan itself blocks the angiotensin II receptor, so combining it with valsartan duplicates this effect. This increases the likelihood of hypotension, syncope, hyperkalemia and acute kidney injury.
How serious is the interaction between Amlodipine-valsartan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; sparsentan labeling contraindicates concomitant ARBs. Stop the ARB before starting sparsentan.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Aldesleukin, Amifostine. The full list is on the Amlodipine-valsartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
