相互作用
Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam
重症度: 中等度
Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam: moderate interaction.
最終更新日
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概要
Colesevelam can bind olmesartan in the gut and lower its absorption, possibly reducing blood pressure control. Binding of hydrochlorothiazide is also possible.
この相互作用をわかりやすく説明すると
Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Colesevelam belongs to Endocrine.
なぜ起こるのか
Bile acid sequestrant binds olmesartan in the gastrointestinal tract, reducing absorption.
対処法
Give the combination tablet at least 4 hours before colesevelam. Monitor blood pressure if dosing cannot be separated.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、Amlodipine-olmesartan-hydrochlorothiazideとColesevelamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-olmesartan-hydrochlorothiazideのその他の相互作用
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide 併用禁忌
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide 併用禁忌
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan 併用禁忌
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide 重大
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide 重大
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide 重大
Colesevelamのその他の相互作用
よくある質問
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Colesevelam?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam can bind olmesartan in the gut and lower its absorption, possibly reducing blood pressure control. Binding of hydrochlorothiazide is also possible.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the combination tablet at least 4 hours before colesevelam. Monitor blood pressure if dosing cannot be separated.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
