Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam can bind olmesartan in the gut and lower its absorption, possibly reducing blood pressure control. Binding of hydrochlorothiazide is also possible.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Colesevelam belongs to Endocrine.
Why it happens
Bile acid sequestrant binds olmesartan in the gastrointestinal tract, reducing absorption.
What to do
Give the combination tablet at least 4 hours before colesevelam. Monitor blood pressure if dosing cannot be separated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Colesevelam
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Cyclosporine Moderate
- Colesevelam + Gliclazide Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Colesevelam?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam can bind olmesartan in the gut and lower its absorption, possibly reducing blood pressure control. Binding of hydrochlorothiazide is also possible.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the combination tablet at least 4 hours before colesevelam. Monitor blood pressure if dosing cannot be separated.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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