相互作用
Colesevelam + Cyclosporin
重症度: 中等度
Colesevelam and Cyclosporin: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Colesevelam can bind cyclosporine in the gut and reduce its absorption, leading to lower blood concentrations and a risk of rejection. Taking cyclosporine well before colesevelam avoids the effect.
この相互作用をわかりやすく説明すると
Colesevelam and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Cyclosporin belongs to Miscellaneous.
なぜ起こるのか
Bile acid sequestrant binds cyclosporine in the gastrointestinal tract, reducing absorption.
対処法
Give cyclosporine at least 4 hours before colesevelam and monitor cyclosporine trough levels.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ColesevelamとCyclosporinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Cyclosporinのその他の相互作用
Colesevelamのその他の相互作用
よくある質問
Can I take Colesevelam with Cyclosporin?
MediHelp rates the interaction as moderate. Colesevelam and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam can bind cyclosporine in the gut and reduce its absorption, leading to lower blood concentrations and a risk of rejection. Taking cyclosporine well before colesevelam avoids the effect.
How serious is the interaction between Colesevelam and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cyclosporine at least 4 hours before colesevelam and monitor cyclosporine trough levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
