相互作用
Amlodipine-perindopril + Candesartan
重症度: 重大
Amlodipine-perindopril and Candesartan: major interaction.
最終更新日
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概要
Perindopril with candesartan produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment without added clinical benefit in most patients.
この相互作用をわかりやすく説明すると
Amlodipine-perindopril and Candesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-perindopril belongs to Cardiovascular; Candesartan belongs to Cardiovascular.
なぜ起こるのか
Additive inhibition of the renin-angiotensin-aldosterone system by ACE inhibition and angiotensin receptor blockade.
対処法
Avoid the combination in most patients. Where it is used, for example in selected heart failure cases, monitor potassium, creatinine and blood pressure closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amlodipine-perindoprilとCandesartanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-perindoprilのその他の相互作用
Candesartanのその他の相互作用
よくある質問
Can I take Amlodipine-perindopril with Candesartan?
MediHelp rates the interaction as major. Amlodipine-perindopril and Candesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Perindopril with candesartan produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment without added clinical benefit in most patients.
How serious is the interaction between Amlodipine-perindopril and Candesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in most patients. Where it is used, for example in selected heart failure cases, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
