相互作用
Candesartan + Sparsentan
重症度: 併用禁忌
Candesartan and Sparsentan: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin receptor blockade. This increases the risk of hypotension, syncope, hyperkalemia and renal function decline.
この相互作用をわかりやすく説明すると
Candesartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Candesartan belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
なぜ起こるのか
Duplicate angiotensin II type 1 receptor blockade producing additive pharmacodynamic effects.
対処法
Do not use together; stop the ARB before starting sparsentan. Monitor blood pressure, potassium and renal function after initiation.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CandesartanとSparsentanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Candesartanのその他の相互作用
Sparsentanのその他の相互作用
よくある質問
Can I take Candesartan with Sparsentan?
MediHelp rates the interaction as contraindicated. Candesartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin receptor blockade. This increases the risk of hypotension, syncope, hyperkalemia and renal function decline.
How serious is the interaction between Candesartan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; stop the ARB before starting sparsentan. Monitor blood pressure, potassium and renal function after initiation.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Amifostine, Amiloride. The full list is on the Candesartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
