相互作用
Amobarbital + Butorphanol
重症度: 重大
Amobarbital and Butorphanol: major interaction.
最終更新日
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概要
Barbiturates and opioids together can cause deep sedation, respiratory depression, coma and death. The risk is greatest at higher doses and in frail or opioid-naive patients.
この相互作用をわかりやすく説明すると
Amobarbital and Butorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Butorphanol belongs to Musculoskeletal.
なぜ起こるのか
Additive CNS and respiratory depression via opioid receptors and enhanced GABA-A activity.
対処法
Avoid if possible; if both are required, use reduced doses with close monitoring of respiratory rate and level of consciousness.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとButorphanolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Butorphanolのその他の相互作用
Amobarbitalのその他の相互作用
よくある質問
Can I take Amobarbital with Butorphanol?
MediHelp rates the interaction as major. Amobarbital and Butorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and opioids together can cause deep sedation, respiratory depression, coma and death. The risk is greatest at higher doses and in frail or opioid-naive patients.
How serious is the interaction between Amobarbital and Butorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are required, use reduced doses with close monitoring of respiratory rate and level of consciousness.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
