相互作用
Amobarbital + Doravirine
重症度: 併用禁忌
Amobarbital and Doravirine: contraindicated interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Barbiturates induce CYP3A4 and can substantially lower doravirine concentrations. This risks loss of virologic suppression and development of resistance. Doravirine labeling advises against strong CYP3A inducers.
この相互作用をわかりやすく説明すると
Amobarbital and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amobarbital belongs to Central Nervous System; Doravirine belongs to Anti Virals.
なぜ起こるのか
Barbiturate-mediated CYP3A4 induction increases doravirine metabolism.
対処法
Avoid the combination and use a non-inducing sedative. If an inducer is unavoidable, use an alternative antiretroviral regimen.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとDoravirineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amobarbitalのその他の相互作用
Doravirineのその他の相互作用
よくある質問
Can I take Amobarbital with Doravirine?
MediHelp rates the interaction as contraindicated. Amobarbital and Doravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates induce CYP3A4 and can substantially lower doravirine concentrations. This risks loss of virologic suppression and development of resistance. Doravirine labeling advises against strong CYP3A inducers.
How serious is the interaction between Amobarbital and Doravirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing sedative. If an inducer is unavoidable, use an alternative antiretroviral regimen.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Elbasvir / grazoprevir, Isavuconazonium. The full list is on the Amobarbital page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
