相互作用
Amobarbital + Dasatinib
重症度: 重大
Amobarbital and Dasatinib: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Amobarbital is an enzyme inducer and may markedly lower dasatinib exposure, which can compromise leukemia control.
この相互作用をわかりやすく説明すると
Amobarbital and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Dasatinib belongs to Oncology.
なぜ起こるのか
Barbiturate induction of CYP3A4 increases dasatinib clearance.
対処法
Use an alternative sedative or anticonvulsant without CYP3A4 induction where possible. If unavoidable, monitor hematologic and molecular response and consider a dasatinib dose increase.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとDasatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Amobarbitalのその他の相互作用
Dasatinibのその他の相互作用
よくある質問
Can I take Amobarbital with Dasatinib?
MediHelp rates the interaction as major. Amobarbital and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital is an enzyme inducer and may markedly lower dasatinib exposure, which can compromise leukemia control.
How serious is the interaction between Amobarbital and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative sedative or anticonvulsant without CYP3A4 induction where possible. If unavoidable, monitor hematologic and molecular response and consider a dasatinib dose increase.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
