相互作用
Amobarbital + Oxazepam
重症度: 重大
Amobarbital and Oxazepam: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Barbiturates and benzodiazepines together produce profound additive CNS and respiratory depression. Risk includes excessive sedation, hypotension, coma and death, particularly with parenteral amobarbital.
この相互作用をわかりやすく説明すると
Amobarbital and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
なぜ起こるのか
Both enhance GABA-A receptor activity at different sites, producing additive CNS and respiratory depression.
対処法
Avoid combining where possible; if required, reduce doses and monitor respiratory rate, oxygen saturation and level of consciousness closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとOxazepamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Oxazepamのその他の相互作用
Amobarbitalのその他の相互作用
よくある質問
Can I take Amobarbital with Oxazepam?
MediHelp rates the interaction as major. Amobarbital and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines together produce profound additive CNS and respiratory depression. Risk includes excessive sedation, hypotension, coma and death, particularly with parenteral amobarbital.
How serious is the interaction between Amobarbital and Oxazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if required, reduce doses and monitor respiratory rate, oxygen saturation and level of consciousness closely.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
