相互作用
Amobarbital + Pazopanib
重症度: 重大
Amobarbital and Pazopanib: major interaction.
最終更新日
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概要
Barbiturates induce CYP3A4, the main metabolic pathway of pazopanib, and may lower its exposure and antitumor efficacy. Pazopanib labeling advises avoiding strong CYP3A4 inducers.
この相互作用をわかりやすく説明すると
Amobarbital and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Pazopanib belongs to Oncology.
なぜ起こるのか
CYP3A4 induction by amobarbital increases pazopanib clearance.
対処法
Avoid combination where possible and use a non-inducing alternative. If unavoidable, monitor tumor response and toxicity closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとPazopanibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amobarbitalのその他の相互作用
Pazopanibのその他の相互作用
よくある質問
Can I take Amobarbital with Pazopanib?
MediHelp rates the interaction as major. Amobarbital and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce CYP3A4, the main metabolic pathway of pazopanib, and may lower its exposure and antitumor efficacy. Pazopanib labeling advises avoiding strong CYP3A4 inducers.
How serious is the interaction between Amobarbital and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible and use a non-inducing alternative. If unavoidable, monitor tumor response and toxicity closely.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
