相互作用
Amoxapine + Thioridazine
重症度: 併用禁忌
Amoxapine and Thioridazine: contraindicated interaction.
最終更新日
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概要
Both drugs can prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Combining them also adds anticholinergic and sedative effects, and thioridazine can raise amoxapine levels.
この相互作用をわかりやすく説明すると
Amoxapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive QT prolongation, with thioridazine inhibiting CYP2D6 metabolism of amoxapine.
対処法
Avoid combining; choose an antidepressant with minimal QT effect. If previously combined, perform ECG and check electrolytes.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmoxapineとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Thioridazineのその他の相互作用
よくある質問
Can I take Amoxapine with Thioridazine?
MediHelp rates the interaction as contraindicated. Amoxapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Combining them also adds anticholinergic and sedative effects, and thioridazine can raise amoxapine levels.
How serious is the interaction between Amoxapine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; choose an antidepressant with minimal QT effect. If previously combined, perform ECG and check electrolytes.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
