相互作用
Amiodarone + Thioridazine
重症度: 併用禁忌
Amiodarone and Thioridazine: contraindicated interaction.
最終更新日
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概要
Amiodarone and thioridazine each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.
この相互作用をわかりやすく説明すると
Amiodarone and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Additive QTc prolongation through hERG potassium channel blockade
対処法
Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Thioridazineのその他の相互作用
よくある質問
Can I take Amiodarone with Thioridazine?
MediHelp rates the interaction as contraindicated. Amiodarone and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amiodarone and thioridazine each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.
How serious is the interaction between Amiodarone and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
