相互作用
Amphotericin b liposomal + Melphalan
重症度: 中等度
Amphotericin b liposomal and Melphalan: moderate interaction.
最終更新日
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概要
Amphotericin B can cause nephrotoxicity and infusion reactions, and melphalan clearance depends partly on renal function, so toxicity may be heightened with combined use. The liposomal form is less nephrotoxic but the concern is not eliminated.
この相互作用をわかりやすく説明すると
Amphotericin b liposomal and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Melphalan belongs to Oncology.
なぜ起こるのか
Possible additive renal toxicity; the mechanism of any wider interaction is not well established.
対処法
Monitor serum creatinine, electrolytes and blood counts, and watch for hypotension or bronchospasm during infusions. Adjust melphalan dose if renal function declines.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amphotericin b liposomalとMelphalanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Melphalanのその他の相互作用
- Adenovirus types 4 and 7 live + Melphalan 併用禁忌
- Bcg vaccine live + Melphalan 併用禁忌
- Influenza virus vaccine quadrivalent intranasal + Melphalan 併用禁忌
- Measles mumps and rubella vaccine live + Melphalan 併用禁忌
- Measles mumps and rubella vaccine + Melphalan 併用禁忌
- Measles mumps rubella and varicella vaccine live + Melphalan 併用禁忌
Amphotericin b liposomalのその他の相互作用
よくある質問
Can I take Amphotericin b liposomal with Melphalan?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Melphalan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B can cause nephrotoxicity and infusion reactions, and melphalan clearance depends partly on renal function, so toxicity may be heightened with combined use. The liposomal form is less nephrotoxic but the concern is not eliminated.
How serious is the interaction between Amphotericin b liposomal and Melphalan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes and blood counts, and watch for hypotension or bronchospasm during infusions. Adjust melphalan dose if renal function declines.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
