相互作用
Aprepitant + Olaparib
重症度: 重大
Aprepitant and Olaparib: major interaction.
最終更新日
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概要
Aprepitant is a moderate CYP3A4 inhibitor and can raise olaparib plasma concentrations. Higher exposure may increase olaparib toxicities such as anemia, nausea and fatigue.
この相互作用をわかりやすく説明すると
Aprepitant and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Olaparib belongs to Oncology.
なぜ起こるのか
Aprepitant inhibits CYP3A4-mediated metabolism of olaparib, increasing its exposure.
対処法
Avoid the combination if possible; if it is required, reduce the olaparib dose as stated in its labeling for moderate CYP3A inhibitors. Monitor for hematologic toxicity and GI effects.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AprepitantとOlaparibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Aprepitantのその他の相互作用
Olaparibのその他の相互作用
よくある質問
Can I take Aprepitant with Olaparib?
MediHelp rates the interaction as major. Aprepitant and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant is a moderate CYP3A4 inhibitor and can raise olaparib plasma concentrations. Higher exposure may increase olaparib toxicities such as anemia, nausea and fatigue.
How serious is the interaction between Aprepitant and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if it is required, reduce the olaparib dose as stated in its labeling for moderate CYP3A inhibitors. Monitor for hematologic toxicity and GI effects.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
