相互作用
Azathioprine + Olaparib
重症度: 重大
Azathioprine and Olaparib: major interaction.
最終更新日
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概要
Both drugs suppress bone marrow function, and combining them may deepen or prolong anemia, neutropenia and thrombocytopenia. This raises the risk of infection and bleeding.
この相互作用をわかりやすく説明すると
Azathioprine and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Olaparib belongs to Oncology.
なぜ起こるのか
Additive myelosuppression, with azathioprine impairing purine synthesis and olaparib inhibiting PARP and causing DNA damage in hematopoietic cells.
対処法
Monitor complete blood counts frequently, especially in the first months of combined therapy. Reduce the dose of one or both drugs or interrupt therapy if cytopenias develop.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AzathioprineとOlaparibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Azathioprineのその他の相互作用
Olaparibのその他の相互作用
よくある質問
Can I take Azathioprine with Olaparib?
MediHelp rates the interaction as major. Azathioprine and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress bone marrow function, and combining them may deepen or prolong anemia, neutropenia and thrombocytopenia. This raises the risk of infection and bleeding.
How serious is the interaction between Azathioprine and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, especially in the first months of combined therapy. Reduce the dose of one or both drugs or interrupt therapy if cytopenias develop.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
