相互作用
Artemether / lumefantrine + Ofloxacin
重症度: 重大
Artemether / lumefantrine and Ofloxacin: major interaction.
最終更新日
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概要
Artemether/lumefantrine and ofloxacin each prolong the QT interval, so combined use increases the risk of serious ventricular arrhythmias. The labeling of artemether/lumefantrine advises caution with other QT-prolonging drugs.
この相互作用をわかりやすく説明すると
Artemether / lumefantrine and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive hERG potassium channel blockade leading to QT prolongation.
対処法
Avoid the combination if an alternative exists. If it is unavoidable, obtain an ECG and correct potassium and magnesium before and during treatment.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Artemether / lumefantrineとOfloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ofloxacinのその他の相互作用
よくある質問
Can I take Artemether / lumefantrine with Ofloxacin?
MediHelp rates the interaction as major. Artemether / lumefantrine and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether/lumefantrine and ofloxacin each prolong the QT interval, so combined use increases the risk of serious ventricular arrhythmias. The labeling of artemether/lumefantrine advises caution with other QT-prolonging drugs.
How serious is the interaction between Artemether / lumefantrine and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is unavoidable, obtain an ECG and correct potassium and magnesium before and during treatment.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
